Pseudothrombocytopenia

Pseudothrombocytopenia:

  • Due to ethylenediaminetetraacetic acid (EDTA)-induced platelet clumping (EDTA: anticoagulant commonly used in tubes for routine CBC)
  • Suspect in asymptomatic patient with low platelet count
  • Repeat platelet count using an anticoagulant other than EDTA (heparin or sodium citrate) -> normal platelet count confirms diagnosis
  • Peripheral smear: shows platelet clumping – results in artificially low platelet count

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