Acute Promyelocytic Leukemia (APL)

Acute Promyelocytic Leukemia (APL):

  • Biologically and clinically distinct variant of AML
  • APL was classified as AML-M3 in the older French-American-British (FAB) classification system and is currently classified as Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA in the World Health Organization classification system.
  • Induction: All-Trans Retinoic Acid (ATRA)
    • Resulted in the highest cure rates of the AML sub
  • High-risk patients:
    • Combination of ATRA and chemotherapy
  • Low-risk patients (WBC ≤ 10):
    • Combination of ATRA and Arsenic Trioxide for induction and consolidation therapy

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